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HERBESSER R100 mg Caps (Diltiazem Hydrochloride)Made by Japan

By, Mitsubishi Tanabe Pharma

Tk.4650

Availability: In Stock

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Product Code: 107147

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Product Full Description | Ratings & Reviews

HERBESSER R100 mg Caps (Diltiazem Hydrochloride)Made by Japan

Description

Diltiazem hydrochloride occurs as white crystals or crystalline powder. It is odorless.

It is very soluble in formic acid, free soluble in water, in methanol and in chloroform, sparingly soluble in acetonitrile, slightly soluble in dehydrated ethanol and in acetic anhydride, and practically insoluble in ether.

Herbesser R100/Herbesser R200: 

Diltiazem hydrochloride dilates blood vessels, improves myocardial ishemia, and exerts antihypertensive effect by inhibiting calcium channel influx to cells in vascular smooth muscles such as coronary vessels, peripheral vessels, etc.

Action on myocardial ishemia: 

Improvment of myocardial oxygen demand and supply balance: It dilates large coronary vessels and collateral channels, and increases blood flow to myocardial ischaemic lesion (dogs).

It inhibits coronary artery spasm (monkeys and humans).

It decreases myocardial oxygen consumption without decreasing cardiac output by afterload reduction due to peripheral vasodilation and decreased heart rate (dogs).

Myocardial protective action: 

It maintains cardiac function and myocardial energy metabolism, and reduces the extension of infarct lesions by inhibiting calcium channel influx to cells at the time of myocardial ischaemia (rats).

Action on blood pressure: 

It has almost no effect on normal blood pressure, while decreases high blood pressure gradually (rats and humans), and inhibits exercise-induced blood pressure elevation (humans).

It does not decrease cerebral and renal blood flow, while decreases blood pressure (dogs and humans).

It inhibits myocardial and vascular hypertrophies along with decreased blood pressure (rats).

Effects on cardiac stimulation and cardiac conduction: 

It slightly prolongs sinus node spontaneous cycle length and slows atrio-ventricular nodal conduction (AH interval), while it does not effect His-Purkinje system conduction (HV interval) (dogs and humans).


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